.png?width=152&height=65&name=a%20ZEON%20company%20(3).png "a ZEON company (3)")
-1.png?width=152&height=65&name=a%20ZEON%20company%20(4)-1.png "Edge")
Label-free cell separation and purification, by size, at scale
Deterministic Cell Separation (DCS) devices available now, for research and process development. No antibodies, no magnetic beads, no centrifuge, and gentle on your cells.
~90% target-cell recovery ~99% platelet removal <1 to 300+ mL research to apheresis
Representative performance of the 4.3 µm device. Not a guaranteed specification.
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Available Now
Choose the device that fits your application
Every DCS device is compatible with off-the-shelf microfluidic controllers and needs only two pressure sources, so you can start separating cells without buying a dedicated instrument.
| Critical diameter | Lanes | Example applications | Capacity and throughput | |
|---|---|---|---|---|
| 4.3 µm | 34 | Purifying WBCs from RBCs and platelets | ~6.5 mL/min, ~60 mL | |
| 4.3 µm | 68 | Purifying WBCs from RBCs and platelets | ~13 mL/min, ~120 mL | |
| 5.5 µm | 20 | Purifying stem cells from WBCs | ~4 mL/min, ~40 to 60 mL | |
| 6.5 µm | 20 | Separating lymphocytes from granulocytes and monocytes | ~4 mL/min, ~40 to 60 mL | |
| 7.5 µm | 20 | Separating lymphocytes from granulocytes and monocytes | ~4 mL/min, ~40 to 60 mL | |
| 8.5 µm | 20 | Isolating tumor-infiltrating lymphocytes from mouse tumors | ~4 mL/min, ~40 to 60 mL |
All devices process fresh blood products (whole blood, apheresis, buffy coats) and cultured or expanded cells. Example applications are illustrative; device performance for a specific application is not guaranteed. All catalog devices are for Research Use Only. No minimum order: buy a single device or scale throughput with more lanes.
Not sure which critical diameter you need? Tell us your target cells or beads, and we will point you to the right device.
WHO IT IS FOR
Three ways teams put DCS to work
EXPLORE CO-DEVELOPMENT
From research to clinical. Every catalog device is for Research Use Only, built for research and process development. When you are ready to move toward clinical manufacturing, we co-develop a custom, regulated path with your team.
Why label-free
Separate cells by size, not by label
Most cell separation still depends on tagging cells with antibodies and magnetic beads, then removing them. DCS sorts cells by their physical size as they flow through a precisely engineered array, so cells stay untouched and naive.
DCS Size-based separation
- No antibodies and no magnetic beads
- Bulk separation by cell size in a single pass
- Gentle on cells: maintains viability, avoids activation
- Runs on controllers you already own
- Flexible buffer system based on off-the-shelf reagents
- Limited or no dilution, process straight from blood or blood product
Bead and antibody methods
- Marker dependent, with added reagent cost
- Typically requires specific concentration ranges and buffer systems
- Often tied to a closed instrument ecosystem
- More handling steps and higher setup
- Lower efficiencies when labeling in whole blood
PROOF
The numbers hold up next to Ficoll
DCS recovers almost 2x more CD3+ T-cells than Ficoll®.
DCS removes >10x more platelets than manual Ficoll®.
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Read the study
Peer-reviewed validation across 150 human samples showed higher leukocyte recovery, improved RBC and platelet depletion, and reduced T-cell activation.
Representative performance of the 4.3 µm device. Not a guaranteed specification.
How it works
See DCS technology in action - efficient cell separation for optimal therapeutic outcomes
Edge Precision is a wholly owned subsidiary of ZEON
Deterministic Cell Separation, simply put
As cells flow through a precisely engineered array of micropillars, larger cells follow one path and smaller cells and diffusible species follow another. That physical sorting is what makes DCS label-free and repeatable.
The same principle scales. Parallelized arrays take you from small research volumes up to full apheresis collections without changing the underlying method.
Mathematically defined array geometries are designed for different critical diameters. Choose the one that fits your target cells.
Ficoll® is a registered trademark owned by GE Healthcare companies.
Ready to discuss your project?
Whether you're exploring feasibility, need prototypes, or are ready to scale — we're here to help.
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